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PDT REVIXAN technology
REVIXAN sparks a chain of photochemical reactions at the cellular level, which cause the following effects:
elimination of disordered or damaged structures in the epidermis and dermis;
normalizing metabolism and proliferation of the cells, stable photoreactivation of cellular DNA, optimizing melanogenesis and angiogenesis.
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The REVIXAN technology is based on innovative developments in the field of photodynamic therapy, i.e. a method based on a photochemical reaction in tissues, which catalys is oxygen activated by a photosensitizer (a substance that increases the sensitivity of tissues to light) under illumination by light of a certain spectral composition.
PDT utilizes three basic components:
  • photosensitizing agent (photosensitizer);
  • monochromatic light source;
  • in vivo contained oxygen.
When foci with accumulated photosensitizer (PS) are exposed to light, photochemical reactions occur in the tissues, which end-product is reactive oxygen species (ROS). These molecules in their low concentration perform regulatory functions, whereas they are highly toxic when the concentration is high, thereby causing damage to pathological cells at the irradiated site.

The PDT REVIXAN technology implies topical application of a PS made on the base of natural molecule derivatives like chlorophyll. The advantages of such PS are its non-toxicity and absence of systemic effects.

When the skin is irradiated by light after being exposed to the REVIXAN-DERMA photosensitizing gel, the generated ROS perform their signaling functions for healthy cells, thereby stimulating their proliferative and synthetic activity, thereby optimally intensifying the physiological regeneration processes in living tissues (particularly, when PDT is combined with invasive treatment modalities).
Major effects of PDT treatment
Improving the appearance of the skin
due to normalization of metabolic processes and mechanisms of skin cell division;
Raising the skin density
by stimulating the proliferation of fibroblasts with a significant enhancement of collagen production in the dermis;
Elimination of fine wrinkles
by reduction in the expression of metalloproteinases in the cutaneous matrix (e.g. MMP-1, MMP-3 and MMP-12), which basically destroy collagen and elastin;
Revitalization of the skin
via enhancing cellular and humoral immunity.
Due to selectively excessive accumulation of photosensitizing agents in damaged, inadequately functioning and pathological cells and the inability to regulate oxidative stress, a cytotoxic reaction develops, which results in final disruption of functioning such cells. This leads to tissue sanitation and prevents adverse cell transformation. According to the study results, lesions of actinic keratosis are eliminated, the number of atypical cells and the degree of atypia of keratinocytes decrease in the epidermis.

After PDT is finalized, there is a decrease in the expression of the p53 gene, an early marker of epidermal carcinogenesis, which may cause a decrease in the carcinogenic potential of photodamaged skin.
The PDT REVIXAN method is in demand in dermatology and cosmetology both as a stand-alone method, as well as in the combined protocols with invasive and non-invasive modalities of aesthetic medicine.
Natalya I. INDILOVA
M.D., dermatologist, cosmetologist, certified international tutor for injection contour plastics and botulinotherapy, lead expert in PDT at the Institute for Plastic Surgery and Cosmetology, awardee of the Golden Lancet prize.

How the PDT REVIXAN treatment takes place

PDT causes the following effects on the healthy cutaneous tissues:
  • normalization in the metabolic processes and mechanisms of skin cell division;
  • stimulation of fibroblast proliferation with a significant increase in collagen production in the dermis;
  • reduction in the expression of metalloproteinases in the cutaneous matrix (e.g. MMP-1, MMP-3 and MMP-12), which basically destroy collagen and elastin;
  • enhancement of the cellular and humoral immunity.

When the skin is irradiated by light after being exposed to REVIXAN-DERMA photosensitizing gel, the generated ROS perform their signaling functions for healthy cells, thereby stimulating their proliferative and synthetic activity, thereby optimally intensifying the physiological regeneration processes in living tissues (particularly when PDT is combined with invasive treatment modalities).
Experience of dermatologists in the PDT REVIXAN technology
Anna VETOSHINA
Dermatologist, cosmetologist
“VESTA” Aesthetic Center, Arkhangelsk city
Yelena MGELADZE
Dermatologist, cosmetologist
“Beauty and Health Alliance” clinic, Moscow
Marina GORBATYKH
Dermatologist, cosmetologist
“Mary Clinic” medical center, Lipetsk city
Diana LAZOVA
Dermatologist, cosmetologist, physiotherapist
"Premium Med" clinic network, Moscow, Kislovodsk city, Pyatigorsk city
Irina SHVETS
Dermatologist, cosmetologist
“VESTA” Aesthetic Center, Arkhangelsk city
Where we perform the PDT REVIXAN treatment
Over 100 clinics across Russia (from Kaliningrad through Vladivostok) as well as in Ukraine, Kazakhstan and some EU contries have been using the PDT REVIXAN technology.
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